Zhou H, Liu Z, Wang Y, et al. Colorectal liver metastasis: molecular mechanism and interventional therapy. Signal Transduction and Targeted Therapy 2022 7:1 2022;7:70-. https://doi.org/10.1038/s41392-022-00922-2.
DOI: 10.1038/s41392-022-00922-2
Tran B, Kopetz S, Tie J, et al. Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer 2011;117:4623–32. https://doi.org/10.1002/CNCR.26086.
DOI: 10.1002/cncr.26086
Carrion-Alvarez L, Primavesi F, Søreide K, et al. Liver metastases from colorectal cancer: A joint ESSO–EAHPBA–UEMS core curriculum collaboration. European Journal of Surgical Oncology 2025;51:109728. https://doi.org/10.1016/j.ejso.2025.109728.
DOI: 10.1016/j.ejso.2025.109728
Salvà F, Saoudi N, Rodríguez M, et al. Determinants of Metastatic Colorectal Cancer With Permanent Liver- Limited Disease. Clin Colorectal Cancer 2024;23:207–14. https://doi.org/10.1016/J.CLCC.2024.05.010.
DOI: 10.1016/j.clcc.2024.05.010
El cáncer en cifras | SEOM: Sociedad Española de Oncología Médica n.d. https://seom.org/prensa/el-cancer-en-cifras.
Los Avances en Cáncer de Colorrectal - SEOM: Sociedad Española de Oncología Médica n.d. https://seom.org/los-avances-en-cancer-de-colorrectal.
Cervantes A, Adam R, Roselló S, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Annals of Oncology 2023;34:10–32. https://doi.org/ 10.1016/j.annonc.2022.10.003.
DOI: 10.1016/j.annonc.2022.10.003
Tirumani SH, Kim KW, Nishino M, et al. Update on the Role of Imaging in Management of Metastatic Colorectal Cancer. Radiographics 2014;34:1908. https://doi.org/10.1148/RG.347130090.
DOI: 10.1148/rg.347130090
Margonis GA, Sasaki K, Gholami S, et al. The Genetic And Morphological Evaluation (GAME) score for patients with Colorectal Liver Metastases. Br J Surg 2018;105:1210. https://doi.org/10.1002/BJS.10838.
DOI: 10.1002/bjs.10838
Renzulli M, Clemente A, Ierardi AM, et al. Imaging of Colorectal Liver Metastases: New Developments and Pending Issues. Cancers (Basel) 2020;12. https://doi.org/ 10.3390/cancers12010151.
DOI: 10.3390/cancers12010151
Simpson AL, Peoples J, Creasy JM, et al. Preoperative CT and survival data for patients undergoing resection of colorectal liver metastases. Scientific Data 2024 11:1 2024;11:172-. https://doi.org/10.1038/s41597-024-02981-2.
DOI: 10.1038/s41597-024-02981-2
Morris VK, Kennedy EB, Baxter NN, et al. Treatment of Metastatic Colorectal Cancer: ASCO Guideline. Journal of Clinical Oncology 2023;41:678–700. https://doi.org/ 10.1200/JCO.22.01690.
DOI: 10.1200/JCO.22.01690
Colon Cancer - Guidelines Detail NCCN n.d. https://www.nccn.org/guidelines/guidelines-detail?id=1428.
Griscom JT, Wolf PS. Liver Metastasis. StatPearls 2023. PMID: 31971757.
Elez E, Yoshino T, Shen L, et al. Encorafenib, Cetuximab, and mFOLFOX6 in BRAF -Mutated Colorectal Cancer . New England Journal of Medicine 2025;392:2425–37. https://doi.org/10.1056/NEJMOA2501912.
DOI: 10.1056/NEJMoa2501912
Filoni E, Musci V, Di Rito A, et al. Multimodal Management of Colorectal Liver Metastases: State of the Art. Oncol Rev 2024;17. https://doi.org/10.3389/OR.2023.11799.
DOI: 10.3389/or.2023.11799
Figaroa OJA, Spaanderman IT, Goedegebuure RSA, et al. Treatment with checkpoint inhibitors for unresectable non-metastatic mismatch repair deficient intestinal cancer; a case series. BJC Reports 2025 3:1 2025;3:67-. https://doi.org/10.1038/s44276-025-00171-0.
DOI: 10.1038/s44276-025-00171-0
Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol 2013;14:1208–15. https://doi.org/10.1016/S1470-2045(13)70447-9.
DOI: 10.1016/S1470-2045(13)70447-9
Montes AF, Alonso V, Aguilar EA, et al. 2025 Updated version v1.0 SEOM-GEMCAD-TTD clinical guidelines for the systemic treatment of metastatic colorectal cancer (2022). Clinical and Translational Oncology 2025;27:1845–50. https://doi.org/10.1007/S12094-025-03860-X/METRICS.
Dekker E, Tanis PJ, Vleugels JLA, et al. Colorectal cancer. The Lancet 2019;394:1467–80. https://doi.org/10.1016/S0140-6736(19)32319-0.
DOI: 10.1016/S0140-6736(19)32319-0
Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1,001 consecutive cases. Ann Surg. 1999 Sep;230(3):309–18.
DOI: 10.1097/00000658-199909000-00004
Russolillo N, Zingaretti CC, Langella S, et al. GAME-SCORE predicts pathological and radiological response to chemotherapy in patients with colorectal liver metastases. European Journal of Surgical Oncology 2024;50:108529. https://doi.org/10.1016/j.ejso.2024.108529.
DOI: 10.1016/j.ejso.2024.108529
Villard C, Abdelrafee A, Habib M, Ndegwa N, Jorns C, Sparrelid E, et al. Prediction of survival in patients with colorectal liver metastases- development and validation of a prognostic score model. Eur J Surg Oncol. 2022 Dec;48(12):2432–9.).
DOI: 10.1016/j.ejso.2022.06.021
Martín-Cullell B, Virgili AC, Riera P, Fumagalli C, Mirallas O, Pelegrín FJ, et al. Histopathological, Clinical, And Molecular (HICAM) score for patients with colorectal liver metastases. Br J Surg. 2024 Mar 2;111(3)).
DOI: 10.1093/bjs/znae016
Itenberg ER, Lozano AM. Surgical and Interventional Management of Liver Metastasis. Clin Colon Rectal Surg 2022;37. https://doi.org/10.1055/S-0042-1758822.
DOI: 10.1055/s-0042-1758822
Ciria R, Ocaña S, Gomez-Luque I, et al. A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer. Surg Endosc 2020;34:349–60. https://doi.org/10.1007/S00464-019-06774-2.
DOI: 10.1007/s00464-019-06774-2
Fichtinger RS, Aldrighetti LA, Abu Hilal M, et al. Laparoscopic Versus Open Hemihepatectomy: The ORANGE II PLUS Multicenter Randomized Controlled Trial. Journal of Clinical Oncology 2024;42:1799. https://doi.org/10.1200/JCO.23.01019.
DOI: 10.1200/JCO.23.01019
Kron P, Lodge P. New trends in surgery for colorectal liver metastasis. Ann Gastroenterol Surg 2024;8:553–65. https://doi.org/10.1002/AGS3.12810.
DOI: 10.1002/ags3.12810
Korenblik R, James S, Smits J, et al. Safety and efficacy of combined portal and hepatic vein embolisation in patients with colorectal liver metastases (DRAGON1): a multicentre, single-arm clinical trial. The Lancet Regional Health - Europe 2025;53:101284. https://doi.org/10.1016/j.lanepe.2025.101284.
DOI: 10.1016/j.lanepe.2025.101284
Gavriilidis P, Marangoni G, Ahmad J, et al. Simultaneous portal and hepatic vein embolization is better than portal embolization or ALPPS for hypertrophy of future liver remnant before major hepatectomy: A systematic review and network meta-analysis. Hepatobiliary Pancreat Dis Int 2023;22:221–7. https://doi.org/10.1016/J.HBPD.2022.08.013.
DOI: 10.1016/j.hbpd.2022.08.013
Hasselgren K, Røsok BI, Larsen PN, et al. ALPPS Improves Survival Compared With TSH in Patients Affected of CRLM: Survival Analysis From the Randomized Controlled Trial LIGRO. Ann Surg 2021;273:442–8. https://doi.org/10.1097/SLA.0000000000003701.
DOI: 10.1097/SLA.0000000000003701
Zheng ZY, Zhang L, Li WL, et al. Laparoscopic associating liver partition and portal vein ligation for staged hepatectomy for colorectal liver metastases: A single-center experience. World J Gastroenterol 2025;31:105530. https://doi.org/10.3748/WJG.V31.I18.105530.
DOI: 10.3748/wjg.v31.i18.105530
Adam R, Kitano Y. Multidisciplinary approach of liver metastases from colorectal cancer. Ann Gastroenterol Surg 2019;3:50. https://doi.org/10.1002/AGS3.12227.
DOI: 10.1002/ags3.12227
Piccolo G, Barabino M, Ghilardi G, et al. Detection and Real-Time Surgical Assessment of Colorectal Liver Metastases Using Near-Infrared Fluorescence Imaging during Laparoscopic and Robotic-Assisted Resections. Cancers 2024, Vol 16, Page 1641 2024;16:1641. https://doi.org/10.3390/cancers16091641.
DOI: 10.3390/cancers16091641
Achterberg FB, Bijlstra OD, Slooter MD, et al. ICG-Fluorescence Imaging for Margin Assessment During Minimally Invasive Colorectal Liver Metastasis Resection. JAMA Netw Open 2024;7:e246548–e246548. https://doi.org/10.1001/jamanetworkopen.2024.6548.
DOI: 10.1001/jamanetworkopen.2024.6548
Bijlstra OD, Dijkhuis TH, Achterberg FB, et al. Preoperative chemotherapy reduces the accumulation of indocyanine green around colorectal liver metastases for use in fluorescence-guided surgery. Surgical Endoscopy 2025:1–12. https://doi.org/10.1007/s00464-025-12034-3.
DOI: 10.1007/s00464-025-12034-3
Adam R, de Gramont A, Figueras J, et al. Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev 2015;41:729–41. https://doi.org/10.1016/J.CTRV.2015.06.006.
DOI: 10.1016/j.ctrv.2015.06.006
Abelson JS, Michelassi F, Sun T, et al. Simultaneous Resection for Synchronous Colorectal Liver Metastasis: the New Standard of Care? Journal of Gastrointestinal Surgery 2017;21:975–82. https://doi.org/10.1007/S11605-017-3422-1.
DOI: 10.1007/s11605-017-3422-1
Martin R, Paty PB, Fong Y, et al. Simultaneous liver and colorectal resections are safe for synchronous colorectal liver metastasis. J Am Coll Surg 2003;197:233–41. https://doi.org/10.1016/S1072-7515(03)00390-9.
DOI: 10.1016/S1072-7515(03)00390-9
O’Connell RM, Hoti E. Challenges and Opportunities for Precision Surgery for Colorectal Liver Metastases. Cancers 2024, Vol 16, Page 2379 2024;16:2379. https://doi.org/10.3390/canceers16132379.
Uhlig J, Lukovic J, Dawson LA, et al. Locoregional Therapies for Colorectal Cancer Liver Metastases: Options Beyond Resection. American Society of Clinical Oncology Educational Book 2021:133–46. https://doi.org/10.1200/EDBK_320519.
DOI: 10.1200/EDBK_320519
Lei S van der, Dijkstra M, Versteeg KS, et al. Surgery versus thermal ablation for small-size colorectal liver metastases (COLLISION): An international, multicenter, phase III randomized controlled trial. Journal of Clinical Oncology 2024;42:LBA3501–LBA3501. https://doi.org/10.1200/JCO.2024.42.17_SUPPL.LBA3501.
DOI: 10.1200/JCO.2024.42.17_suppl.LBA3501
Wasan HS, Gibbs P, Sharma NK, Taieb J, Heinemann V, Ricke J, et al. First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global: a combined analysis of three multicentre, randomised, phase 3 trials. Lancet Oncol. 2017 Sep;18(9):1159–71.
Mulcahy MF, Mahvash A, Pracht M, Montazeri AH, Bandula S, Martin RCG, et al. Radioembolization With Chemotherapy for Colorectal Liver Metastases: A Randomized, Open-Label, International, Multicenter, Phase III Trial. J Clin Oncol. 2021 Dec 10;39(35):3897–907.
DOI: 10.1200/JCO.21.01839
Deschamps F, Elias D, Goere D, et al. Intra-arterial hepatic chemotherapy: a comparison of percutaneous versus surgical implantation of port-catheters. Cardiovasc Intervent Radiol 2011;34:973–9. https://doi.org/10.1007/S00270-010-9996-6.
DOI: 10.1007/s00270-010-9996-6
Lévi FA, Boige V, Hebbar M, et al. Conversion to resection of liver metastases from colorectal cancer with hepatic artery infusion of combined chemotherapy and systemic cetuximab in multicenter trial OPTILIV. Ann Oncol 2016;27:267–74. https://doi.org/10.1093/ANNONC/MDV548.
DOI: 10.1093/annonc/mdv548
Goéré D, Pignon JP, Gelli M, Elias D, Benhaim L, Deschamps F, et al. Postoperative hepatic arterial chemotherapy in high-risk patients as adjuvant treatment after resection of colorectal liver metastases - a randomized phase II/III trial – PACHA-01 (NCT02494973). BMC Cancer. 2018 Dec 6;18(1):787.
DOI: 10.1186/s12885-018-4697-7
Wang L, Zhang T, Pan Q, et al. A phase II study to evaluate the efficacy and safety of fruquintinib combined with tislelizumab and hepatic artery infusion chemotherapy (HAIC) for advanced colorectal cancer liver metastases: An updated analysis of survival. Journal of Clinical Oncology 2024;42:3543–3543. https://doi.org/10.1200/JCO.2024.42.16_SUPPL.3543.
DOI: 10.1200/JCO.2024.42.16_suppl.3543
Dueland S, Smedman TM, Syversveen T, et al. Long-Term Survival, Prognostic Factors, and Selection of Patients With Colorectal Cancer for Liver Transplant: A Nonrandomized Controlled Trial. JAMA Surg 2023;158:e232932–e232932. https://doi.org/10.1001/JAMASURG.2023.2932.
DOI: 10.1001/jamasurg.2023.2932
Tariq Z, Faisal A, Maheswaran S, et al. Liver Transplantation for Colorectal Liver Metastasis: A Comprehensive Review of Current Practices and Future Trends. Livers 2025, Vol 5, Page 44 2025;5:44. https://doi.org/10.3390/LIVERS5030044.
DOI: 10.3390/livers5030044
Ros J, Salva F, Dopazo C, et al. Liver transplantation in metastatic colorectal cancer: are we ready for it? Br J Cancer 2023;128:1797–806. https://doi.org/10.1038/S41416-023-02213-1.
DOI: 10.1038/s41416-023-02213-1
Adam R, Piedvache C, Chiche L, et al. Chemotherapy and liver transplantation versus chemotherapy alone in patients with definitively unresectable colorectal liver metastases: A prospective multicentric randomized trial (TRANSMET). Journal of Clinical Oncology 2024;42:3500–3500. https://doi.org/10.1200/JCO.2024.42.16_SUPPL.3500.
DOI: 10.1200/JCO.2024.42.16_suppl.3500
Maspero M, Sposito C, Virdis M, et al. Liver Transplantation for Hepatic Metastases from Colorectal Cancer: Current Knowledge and Open Issues. Cancers (Basel) 2023;15:345. https://doi.org/10.3390/cancers15020345.
DOI: 10.3390/cancers15020345
Dueland S, Syversveen T, Solheim JM, et al. Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases. Ann Surg 2020;271:212–8. https://doi.org/10.1097/SLA.0000000000003404.
DOI: 10.1097/SLA.0000000000003404
Solheim JM, Dueland S, Line PD, et al. Transplantation for Nonresectable Colorectal Liver Metastases: Long-Term Follow-Up of the First Prospective Pilot Study. Ann Surg 2023;278:239–45. https://doi.org/10.1097/SLA.0000000000005703.
DOI: 10.1097/SLA.0000000000005703
Bonney GK, Chew CA, Lodge P, et al. Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines. Lancet Gastroenterol Hepatol 2021;6:933–46. https://doi.org/ 10.1016/S2468-1253(21)00219-3.
Mergental H, Laing RW, Kirkham AJ, et al. Transplantation of discarded livers following viability testing with normothermic machine perfusion. Nat Commun 2020;11. https://doi.org/10.1038/S41467-020-16251-3.
DOI: 10.1038/s41467-020-16251-3
Königsrainer A, Templin S, Capobianco I, et al. Paradigm Shift in the Management of Irresectable Colorectal Liver Metastases: Living Donor Auxiliary Partial Orthotopic Liver Transplantation in Combination With Two-stage Hepatectomy (LD-RAPID). Ann Surg 2019;270:327–32. https://doi.org/10.1097/SLA.0000000000002861.
DOI: 10.1097/SLA.0000000000002861
Patel RK, Rahman S, Schwantes IR, et al. Updated Management of Colorectal Cancer Liver Metastases: Scientific Advances Driving Modern Therapeutic Innovations. Cell Mol Gastroenterol Hepatol 2023;16:881. https://doi.org/10.1016/J.JCMGH.2023.08.012.
DOI: 10.1016/j.jcmgh.2023.08.012
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