Revisiones en Cáncer H0168
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Revisión

Carcinoma inflamatorio de mama


Publicado: 2023-03-29

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El carcinoma inflamatorio de mama es una entidad infrecuente, pero representa una presentación agresiva del cáncer de mama. A pesar de los avances en cáncer de mama, el pronóstico del carcinoma inflamatorio sigue siendo pobre. Los estudios son retrospectivos, con muestras pequeñas o extrapolaciones del carcinoma de mama no inflamatorio. No obstante, hay suficiente evidencia para sugerir que difiere del no inflamatorio. El manejo óptimo se basa en un tratamiento multimodal que consiste en quimioterapia neoadyuvante, cirugía y radioterapia. El tratamiento sistémico se basa en esquemas de quimioterapia basados en antraciclinas y taxanos. En enfermedad HER2 positiva debe asociarse doble bloqueo con trastuzumab y pertuzumab, lo que genera un incremento de respuesta completa patológica. La mastectomía con linfadenectomía continúa siendo el tratamiento estándar, independientemente de la respuesta a la quimioterapia neoadyuvante. La investigación traslacional puede ayudar a aclarar la etiología y la biología de esta entidad agresiva.

Palabras Clave: Carcinoma inflamatorio de mama. Tratamiento neoadyuvante. Pronóstico.



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