Revisiones en Cáncer 00069 / http://dx.doi.org/10.20960/revcancer.00069
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Revisión

Carcinoma de cabeza y cuello en pacientes no candidatos a platino


Zara Vidales Sepúlveda, Marc Oliva Bernal

Prepublicado: 2024-03-21
Publicado: 2024-07-03

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El cisplatino es un componente esencial del tratamiento del carcinoma escamoso de cabeza y cuello, tanto en la enfermedad localmente avanzada como en la recurrente/metastásica. Sin embargo, la toxicidad aguda y crónica del cisplatino no es asumible en todos los pacientes; está contraindicado absoluta o relativamente en diferentes situaciones clínicas. A lo largo de este trabajo se resume la evidencia disponible de combinaciones libres de cisplatino para el tratamiento de la enfermedad en fase localmente avanzada y en fase recurrente-metastásica.

Palabras Clave: Inelegible para cisplatino. Frágil. Tratamiento adaptado.



Ahn MJ, D’Cruz A, Vermorken JB, Chen JP, Chitapanarux I, Dang HQT, et al. Clinical recommendations for defining platinum unsuita- ble head and neck cancer patient populations on chemoradiother- apy: A literature review. Oral Oncol 2016;53:10-6.
DOI: 10.1016/j.oraloncology.2015.11.019
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet (London, England) 2013;381(9868):752-62.
DOI: 10.1016/S0140-6736(12)62167-9
Argiris A, Li Y, Murphy BA, Langer CJ, Forastiere AA. Outcome of elderly patients with recurrent or metastatic head and neck cancer treated with cisplatin-based chemotherapy. J Clin Oncol 2004;22(2):262-8.
DOI: 10.1200/JCO.2004.08.039
Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, et al. Meta-analysis of chemotherapy in head and neck cancer (MACH- NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group. Radiother Oncol 2021;156:281-93.
DOI: 10.1016/j.radonc.2021.01.013
Ward MC, Reddy CA, Adelstein DJ, Koyfman SA. Use of systemic therapy with definitive radiotherapy for elderly patients with head and neck cancer: A National Cancer Data Base analysis. Cancer 2016;122(22):3472-83.
DOI: 10.1002/cncr.30214
Mayer A, Wenzel W, Wollschläger D, Bostel T, Krüger M, Matthias C, et al. Adjuvant chemoradiotherapy in elderly patients with head and neck cancer: a monoinstitutional, two-to-one pair-matching analysis. Strahlentherapie und Onkol 2022;198(2):159-70.
DOI: 10.1007/s00066-021-01890-2
Smile TD, Reddy CA, Matia B, Fleming CW, Domb C, Geiger JL, et al. A Reappraisal of Definitive Chemoradiotherapy for Older Adults with Advanced Head and Neck Cancer. Anticancer Res 2022;42(8):3845-52.
DOI: 10.21873/anticanres.15875
Falco A, de Oliveira TB, Cacicedo J, Ospina AV, Ticona MÁ, Galin- do H, et al. Ibero-american expert consensus on squamous cell carcinoma of the head and neck treatment in patients unable to receive cisplatin: Recommendations for clinical practice. Cancer Manag Res 2021;13:6689-703.
DOI: 10.2147/CMAR.S322411
Ghadjar P, Hayoz S, Zimmermann F, Bodis S, Kaul D, Badakhshi H, et al. Impact of weight loss on survival after chemoradiation for locally advanced head and neck Cancer: Secondary results of a randomized phase III trial (SAKK 10/94). Radiat Oncol 2015;10(1):1-7.
DOI: 10.1186/s13014-014-0319-y
De Castro G, Alves GV, Castro AF, Chaves ALF, De Marchi P, de Oliveira TB, et al. Criteria for eligibility to cisplatin in the curative treatment of head and neck cancer: Consensus opinion from a panel of experts. Crit Rev Oncol Hematol 2018;131:30-4.
DOI: 10.1016/j.critrevonc.2018.08.009
Marur S, Forastiere AA. Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment. Mayo Clin Proc 2016;91(3):386-96.
DOI: 10.1016/j.mayocp.2015.12.017
Bakas AT, Polinder-Bos HA, Streng F, Mattace-Raso FUS, Ziere G, de Jong RJB, et al. Frailty in Non-geriatric Patients with Head and Neck cancer. Otolaryngol - Head Neck Surg (United States) 2023;169(5):1215-24.
DOI: 10.1002/ohn.388
Handforth C, Clegg A, Young C, Simpkins S, Seymour MT, Selby PJ, et al. The prevalence and outcomes of frailty in older cancer patients: A systematic review. Ann Oncol 2015;26(6):1091-101.
DOI: 10.1093/annonc/mdu540
Wildiers H, Heeren P, Puts M, Topinkova E, Janssen-Heijnen MLG, Extermann M, et al. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol Off J Am Soc Clin Oncol 2014;32(24):2595-603.
DOI: 10.1200/JCO.2013.54.8347
Goede V. Frailty and Cancer: Current Perspectives on Assessment and Monitoring. Clin Interv Aging 2023;18:505-12.
DOI: 10.2147/CIA.S365494
Decoster L, Van Puyvelde K, Mohile S, Wedding U, Basso U, Colloca G, et al. Screening tools for multidimensional health problems war- ranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Ann Oncol Off J Eur Soc Med Oncol 2015;26(2):288-300.
DOI: 10.1093/annonc/mdu210
Swartz LK, Swiecicki PL. Head and Neck Cancers. Oncol Board Rev Bluepr Study Guid. Q&A Third Ed; 2021. p. 185-95.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V. Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS–ESMO–ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2020;31(11):1462-75.
DOI: 10.1016/j.annonc.2020.07.011
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, et al. SEOM clinical guidelines for the treatment of head and neck cancer (2020). Clin Transl Oncol 2021;23(5):913-21.
DOI: 10.1007/s12094-020-02533-1
Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, et al. Final results of the 94-01 French head and neck oncology and radio- therapy group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol 2004;22(1):69-76.
DOI: 10.1200/JCO.2004.08.021
Li Q, Guan J, Zhang Y, Chen M, Li L, Xiao N, et al. A meta-analysis comparing cisplatin-based to carboplatin-based chemotherapy in moderate to advanced squamous cell carcinoma of head and neck (SCCHN). J Clin Oncol 2015;33(Suppl.15):6036-6036.
DOI: 10.1200/jco.2015.33.15_suppl.6036
Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomized trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010;11(1):21-8.
DOI: 10.1016/S1470-2045(09)70311-0
Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, et al. Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet 2019;393(10166):51-60.
DOI: 10.1016/S0140-6736(18)32752-1
Gillison ML, Trotti AM, Harris J, Eisbruch A, Harari PM, Adelstein DJ, et al. Radiotherapy plus cetuximab or cisplatin in human pap- illomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial. Lancet (Lon- don, England) 2019;393(10166):40-50.
DOI: 10.1016/S0140-6736(18)32779-X
Patil VM, Noronha V, Menon N, Singh A, Ghosh-Laskar S, Budrukkar A, et al. Results of Phase III Randomized Trial for Use of Docetaxel as a Radiosensitizer in Patients with Head and Neck Cancer, Unsuit- able for Cisplatin-Based Chemoradiation. J Clin Oncol Off J Am Soc Clin Oncol 2023;41(13):2350-61.
DOI: 10.1200/JCO.22.00980
Lacas B, Bourhis J, Overgaard J, Zhang Q, Grégoire V, Nankiv- ell M, et al. Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis. Lancet Oncol 2017;18(9):1221-37.
DOI: 10.1016/S1470-2045(17)30458-8
Weiss J, Gilbert J, Deal AM, Weissler M, Hilliard C, Chera B, et al. Induction chemotherapy with carboplatin, nab-paclitaxel and cetuximab for at least N2b nodal status or surgically unresecta- ble squamous cell carcinoma of the head and neck. Oral Oncol 2018;84:46-51.
DOI: 10.1016/j.oraloncology.2018.06.028
Martínez-Trufero J, Lozano Borbalas A, Pajares Bernad I, Taberna Sanz M, Ortega Izquierdo E, Cirauqui Cirauqui B, et al. Sequential chemotherapy regimen of induction with panitumumab and pacl- itaxel followed by radiotherapy and panitumumab in patients with locally advanced head and neck cancer unfit for platinum deriv- atives. The phase II, PANTERA/TTCC-2010-06 study. Clin Transl Oncol 2021;23(8):1666-77.
DOI: 10.1007/s12094-021-02567-z
Siu LL, Waldron JN, Chen BE, Winquist E, Wright JR, Nabid A, et al. Effect of standard radiotherapy with cisplatin vs accelerated radi- otherapy with panitumumab in locoregionally advanced squamous cell head and neck carcinoma a randomized clinical trial. JAMA Oncol 2017;3(2):220-6.
DOI: 10.1001/jamaoncol.2016.4510
Patil VM, Noronha V, Joshi A, Muddu VK, Dhumal S, Arya S, et al. Weekly chemotherapy as Induction chemotherapy in local- ly advanced head and neck cancer for patient’s ineligible for 3 weekly maximum tolerable dose chemotherapy. Indian J Cancer 2014;51(1):20-4.
DOI: 10.4103/0019-509X.134608
Shirasu H, Yokota T, Kawakami T, Hamauchi S, Onozawa Y, Ogawa H, et al. Efficacy and feasibility of induction chemotherapy with paclitaxel, carboplatin and cetuximab for locally advanced unre- sectable head and neck cancer patient’s ineligible for combination treatment with docetaxel, cisplatin, and 5-fluorouracil. Int J Clin Oncol 2020;25(11):1914-20.
DOI: 10.1007/s10147-020-01742-6
Marín-Jiménez JA, Oliva M, Peinado Martín P, Cabezas-Camarero S, Plana Serrahima M, Vázquez Masedo G, et al. Paclitaxel Plus Cetuximab as Induction Chemotherapy for Patients With Locore- gionally Advanced Head and Neck Squamous Cell Carcinoma Unfit for Cisplatin-Based Chemotherapy. Front Oncol 2022;12:1-10.
DOI: 10.3389/fonc.2022.953020
Harari PM, Harris J, Kies MS, Myers JN, Jordan RC, Gillison ML, et al. Postoperative chemoradiotherapy and cetuximab for high-risk squamous cell carcinoma of the head and neck: Radiation Therapy Oncology Group RTOG-0234. J Clin Oncol 2014;32(23):2486-95.
DOI: 10.1200/JCO.2013.53.9163
Ngamphaiboon N, Chairoungdua A, Dajsakdipon T, Jiarpinitnun C. Oral Oncology 2023;145.
DOI: 10.1016/j.oraloncology.2023.106520
Tao Y, Biau J, Sun XS, Sire C, Martin L, Alfonsi M, et al. Pembroli- zumab versus cetuximab concurrent with radiotherapy in patients with locally advanced squamous cell carcinoma of head and neck unfit for cisplatin (GORTEC 2015-01 PembroRad): a multicenter, randomized, phase II trial. Ann Oncol 2023;34(1):101-10.
DOI: 10.1016/j.annonc.2022.10.006
Bourhis J, Tao Y, Sun X, Sire C, Martin L, Liem X, et al. LBA35 Ave- lumab-cetuximab-radiotherapy versus standards of care in patients with locally advanced squamous cell carcinoma of head and neck (LA-SCCHN): Randomized phase III GORTEC-REACH trial. Ann Oncol 2021;32(I):S1310.
DOI: 10.1016/j.annonc.2021.08.2112
Thomson DJ, Slevin NJ, Baines H, Betts G, Bolton S, Evans M, et al. Randomized Phase 3 Trial of the Hypoxia Modifier Nimorazole Added to Radiation Therapy with Benefit Assessed in Hypoxic Head and Neck Cancers Determined Using a Gene Signature (NIM- RAD). Int J Radiat Oncol Biol Phys 2023;S0360-3016(23)08184-1.
Karam SD, Reddy K, Blatchford PJ, Waxweiler T, DeLouize AM, Oweida A, et al. Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer. Clin cancer Res an Off J Am Assoc Cancer Res 2018;24(20):4949-59.
DOI: 10.1158/1078-0432.CCR-18-0467
Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, et al. Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer. N Engl J Med 2008;359(11):1116-27.
DOI: 10.1056/NEJMoa0802656
Ferris RL, Blumenschein G, Fayette J, Guigay J, Colevas AD, Licitra L, et al. Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck. N Engl J Med 2016;375(19):1856-67.
DOI: 10.1056/NEJMoa1602252
Burtness B, Rischin D, Greil R, Soulières D, Tahara M, de Castro G, et al. Pembrolizumab Alone or with Chemotherapy for Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma in KEY- NOTE-048: Subgroup Analysis by Programmed Death Ligand-1 Combined Positive Score. J Clin Oncol 2022;40(21):2321-32.
DOI: 10.1200/JCO.21.02198
Guigay J, Aupérin A, Fayette J, Saada-Bouzid E, Lafond C, Taber- na M, et al. Cetuximab, docetaxel, and cisplatin versus platinum, fluorouracil, and cetuximab as first-line treatment in patients with recurrent or metastatic head and neck squamous-cell carcinoma (GORTEC 2014-01 TPExtreme): a multicentre, open-label, ran- domised, phas. Lancet Oncol 2021;22(4):463-75.
DOI: 10.1016/S1470-2045(20)30755-5
Hanai N, Shimizu Y, Kariya S, Yasumatsu R, Yokota T, Fujii T, et al. Effectiveness and safety of nivolumab in patients with head and neck cancer in Japanese real-world clinical practice: a multicenter retrospective clinical study. Int J Clin Oncol 2021;26(3):494-506.
DOI: 10.1007/s10147-020-01829-0
Thapa DA, Cowell DA, Peters DA, Noble DDJ, James DA, Lamb DC, et al. The UK Divide: Does having a Pembrolizumab-Chemotherapy option in head and neck cancer matter? Real-world experience of first-line palliative pembrolizumab monotherapy and pem- brolizumab-chemotherapy combination in Scotland. Clin Oncol (R Coll Radiol) 2024:S0936-6555(24)00071-2.
DOI: 10.1101/2023.06.08.23290541
Wu Q, Wang Q, Tang X, Xu R, Zhang L, Chen X, et al. Correlation between patients’ age and cancer immunotherapy efficacy. Oncoimmunology 2019;8(4):1-9.
Gomes F, Lorigan P, Woolley S, Foden P, Burns K, Yorke J, et al. A prospective cohort study on the safety of checkpoint inhibi- tors in older cancer patients – the ELDERS study. ESMO Open 2021;6(1):100042.
DOI: 10.1016/j.esmoop.2020.100042
Hitt R, Irigoyen A, Cortes-Funes H, Grau JJ, García-Sáenz JA, Cruz-Hernández JJ. Phase II study of the combination of cetux- imab and weekly paclitaxel in the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of head and neck. Ann Oncol 2012;23(4):1016-22.
DOI: 10.1093/annonc/mdr367
Rubió-Casadevall J, Cirauqui Cirauqui B, Martínez Trufero J, Plana Serrahima M, García Castaño A, Carral Maseda A, et al. TTCC- 2019-02: real-world evidence of first-line cetuximab plus paclitaxel in recurrent or metastatic squamous cell carcinoma of the head and neck. Front Oncol 2023;13:1-14.
DOI: 10.3389/fonc.2023.1226939
Burtness B, Harrington KJ, Greil R, Soulières D, Tahara M, de Castro G, et al. Pembrolizumab alone or with chemotherapy versus cetuxi- mab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet 2019;394(10212):1915-28.
DOI: 10.1016/S0140-6736(19)32591-7
Harrington KJ, Burtness B, Greil R, Soulières D, Tahara M, de Castro G, et al. Pembrolizumab With or Without Chemotherapy in Recur- rent or Metastatic Head and Neck Squamous Cell Carcinoma: Updated Results of the Phase III KEYNOTE-048 Study. J Clin Oncol 2023;41(4):790-802.
DOI: 10.1200/JCO.21.02508
Dzienis MR, Cundom JE, Fuentes CS, Hansen AR, Nordlinger MJ, Pastor AV, et al. 651O Pembrolizumab (pembro) + carboplatin (car- bo) + paclitaxel (pacli) as first-line (1L) therapy in recurrent/met- astatic (R/M) head and neck squamous cell carcinoma (HNSCC): Phase VI KEYNOTE-B10 study. Ann Oncol 2022;33:S839-40.
DOI: 10.1016/j.annonc.2022.07.775
Haddad RI, Harrington K, Tahara M, Ferris RL, Gillison M, Fayette J, et al. Nivolumab Plus Ipilimumab Versus EXTREME Regimen as First-Line Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: The Final Results of CheckMate 651. J Clin Oncol 2023;41(12):2166-80.
DOI: 10.1200/JCO.22.00332
Psyrri A, Fayette J, Harrington K, Gillison M, Ahn MJ, Takahashi S, et al. Durvalumab with or without tremelimumab versus the EXTREME regimen as first-line treatment for recurrent or metastatic squa- mous cell carcinoma of the head and neck: KESTREL, a rand- omized, open-label, phase III study. Ann Oncol 2023;34(3):262-74.
DOI: 10.1016/j.annonc.2022.12.008
Fayette J, Licitra LFL, Harrington KJ, Haddad R, Siu LL, Liu YC, et al. 854O INTERLINK-1: Phase III study of cetuximab (CTX) ± monal- izumab (M) in participants (pts) with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) with disease progression on/after platinum chemotherapy (CT) and previous- ly treated with an immune checkpoint inhibitor (ICI). Ann Oncol 2023;34:S554-5.
DOI: 10.1016/j.annonc.2023.09.2000
Kong AH, Klein Hesselink MS, Aguilera B, Adkins D, Even C, Fayette J, et al. Phase 2 study of ISA101b (peltopepimut-S) and cemiplimab in patients with advanced HPV16+ oropharyngeal cancer who failed anti-PD1 therapy. J Clin Oncol 2023;41(Suppl.16):6028-6028.
DOI: 10.1200/JCO.2023.41.16_suppl.6028
Sacco AG, Chen R, Worden FP, Wong DJL, Adkins D, Swiecicki P, et al. Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-la- bel, multi-arm, non-randomised, multicentre, phase 2 trial. Lancet Oncol 2021;22(6):883-92.
DOI: 10.1016/S1470-2045(21)00136-4
Bauman J, Cancer GW. 2024 Multidisciplinary Head and Neck Cancers 2024 Multidisciplinary Head and Neck Cancers Sympo- sium; 2024.
Melero I, Castanon E, Álvarez M, Champiat S, Marabelle A. Intra- tumoural administration and tumour tissue targeting of cancer immunotherapies. Nat Rev Clin Oncol 2021;18(9):558-76.
DOI: 10.1038/s41571-021-00507-y
Fayette J, Cropet C, Gautier J, Toullec C, Burgy M, Bruyas A, et al. Results of the multicenter phase II FRAIL-IMMUNE trial evaluat- ing the efficacy and safety of durvalumab combined with weekly paclitaxel carboplatin in first-line in patients (pts) with recurrent/ metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) not eligible for cisplatin-based therapies. J Clin Oncol 2023;41(Suppl.16):6003-6003.
DOI: 10.1200/JCO.2023.41.16_suppl.6003

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