Revisiones en Cáncer 00027 / http://dx.doi.org/10.20960/revcancer.00027
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Revisión

Tratamiento del cáncer de mama luminal tras inhibidores de ciclo celular


Rodrigo Sánchez Bayona, Manuel Alva Bianchi

Prepublicado: 2023-07-12
Publicado: 2023-07-12

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La elección del tratamiento para aquellas pacientes que experimentan progresión tras inhibidores de CDK4/6 sigue siendo un desafío debido a la actividad subóptima o a las toxicidades significativas de las opciones actualmente disponibles. También hay pocos datos sobre la eficacia de combinaciones más antiguas, como everolimus + exemestano, tras inhibidores de CDK4/6. Ensayos clínicos recientes con nuevos fármacos han arrojado resultados prometedores en este contexto. No obstante, el estado de mutación de ESR1, PIK3CA y BRCA1/2 de la línea germinal son aspectos a tener en cuenta para las nuevas opciones disponibles (inhibidores de PI3K, nuevos SERD orales, inhibidores de PARP). Los nuevos anticuerpos conjugados (trastuzumab deruxtecán y sacituzumab govitecán) también han demostrado ser una opción eficaz de tratamiento en pacientes con cáncer de mama RH+/HER2-. En este artículo de revisión, resumimos la actividad de estas nuevas opciones de tratamiento y su papel potencial en futuros algoritmos de tratamiento.

Palabras Clave: SERD. PI3K. ESR1. Anticuerpos conjugados.



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