Revisiones en Cáncer 00025 / http://dx.doi.org/10.20960/revcancer.00025
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Revisión

Más allá de la primera línea del cáncer del mama metastásico HER2+


Carmen Salvador-Coloma

Prepublicado: 2023-07-12
Publicado: 2023-07-17

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El cáncer de mama HER2 positivo es uno de los tumores más agresivos. Se han desarrollado muchos agentes terapéuticos nuevos que permiten una importante mejoría en el pronóstico de estas pacientes. En primera línea, el estándar de tratamiento continúa siendo el doble bloqueo asociado a un taxano. Recientemente, los conjugados anticuerpo-fármaco de nueva generación han dado lugar a unos resultados sin precedentes, y se ha establecido el trastuzumab deruxtecán como un nuevo estándar en segunda línea. A pesar de los avances en el desarrollo terapéutico, la mayoría de las pacientes presentan resistencias y finalmente recaen. La esperanza de vida disminuye con cada línea adicional de tratamiento. En respuesta a esta necesidad, se están explorando nuevos mecanismos, agentes dirigidos y combinaciones de fármacos que tratan de modificar la historia natural del cáncer de mama metastásico HER2 positivo.

Palabras Clave: Cáncer de mama metastásico. HER2 positivo. Segunda línea de tratamiento. Tratamiento dirigido. Trastuzumab. Anticuerpos conjugados.



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