Revisión

Avances en el manejo de las metástasis cerebrales por cáncer de mama

Carmen Hinojo Gonzalez, Lucía Andrea Alonso Buznego, Pablo Jara Martín

Prepublicado: 2023-07-12

Publicado: 2023-07-17

VOLUMEN 37, NÚM. 2, marzo-abril (2023), PAG. 98-104

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El cáncer de mama es la segunda causa más frecuente de metástasis cerebrales. Su incidencia ha aumentado en los últimos años, especialmente en las pacientes con tumores de mama triple negativo o HER2 positivo. La supervivencia varía ampliamente en función de una serie de factores pronósticos. El abordaje de las metástasis cerebrales en cáncer de mama diseminado requiere un manejo multidisciplinar, con cambios en los últimos años, que conducen a un mayor empleo del tratamiento sistémico y a la radioterapia estereotáctica (SRS). Disponemos de resultados especialmente prometedores con nuevos fármacos anti-HER2 y con conjugados anti cuerpo-fármaco (ADC). A pesar de la mejoría en los tratamientos, las metástasis cerebrales en cáncer de mama siguen siendo un reto terapéutico. Los esfuerzos se centran en su prevención, su diagnóstico precoz y en la búsqueda de tratamientos eficaces.

Palabras Clave: Cáncer de mama avanzado. Metástasis cerebrales. Sistema nervioso central (SNC).

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