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Carcinomas de ovario: características clínico-patológicas y moleculares. Comentarios sobre la estadificación FIGO 2014


Jaime Prat, Emanuela D´Angelo, Íñigo Espinosa

Prepublicado: 2024-11-08

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Según el tipo celular y las alteraciones genéticas se distinguen cinco tipos principales de carcinoma de ovario que, en conjunto, representan más del 95 % del total. Por orden de frecuencia son: a) carcinomas serosos de alto grado (70 %); b) carcinomas endometrioides (10 %); c) carcinomas de células claras (10 %); d) carcinomas mucinosos (3-4 %); y e) carcinomas serosos de bajo grado (< 5 %). Se trata de 5 enfermedades distintas que difieren notablemente en cuanto al pronóstico y tratamiento. En esta revisión se destacan los recientes avances en patología y genética molecular que, no solo han permitido conocer mejor la patogenia de estos cánceres, sino también han contribuido a mejorar notablemente el tratamiento de las pacientes. Asimismo, se reevalúa la estadificación FIGO que propusimos hace una década.

Palabras Clave: Ovario. Carcinoma seroso de alto grado. Carcinoma endometrioide. Carcinoma de células claras. Carcinoma mucinoso. Carcinoma seroso de bajo grado.



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